Research Roundup: What is THCP, THCV, THCB, and how are they different than THC?

There are over 100 cannabinoids found in Cannabis and we are still finding new compounds in the plant. A few new cannabinoids were recently found in the cannabis plant. These cannabinoids have been synthesized before, but this is the first time we are finding these in the plant itself.

THCP (tetrahydrocannabiphorol), along with CBDP (cannabidiphorol), has recently been detected in the cannabis plant. THCB has also been isolated from cannabis as well. This is exciting, but how are these compounds different than THC?

The way the structures are drawn, there is a (carbon) “tail” at the right. Each branch point represents one carbon. The “tail” on THC has 5 carbons (labeled in red below), THCV has 3 carbons, THCB has 4 carbons, and THCP has 7 carbons. This small difference can drastically affect how the molecules act on their targets in the body (e.g. CB1 receptors). The study suggests that THCP might be up to 30 times stronger than THC at CB1 receptors. So, this would lead to an increased high associated with that cannabis product.